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Canine Tumors and Cancers
University of
Missouri-Columbia Scott Endowed Program in Veterinary Oncology
The most
common forms of cancer are breast, skin, bone, connective tissue, oral, and lymphoma.
While some cancer, such as breast cancer, is largely preventable
with early spaying, the cause of most cancers is not known and therefore prevention is
difficult. Bone tumors are commonly seen in the leg bones, near joints, persistent
lameness and swelling of the leg an early sign of disease. Testicular tumors are seen in
dogs with retained testes, but are often curable with surgery. Tumors inside the abdomen
are common but it can be difficult to make an early diagnosis. Weight loss and abdominal
enlargement are common signs of these tumors. With cancer of the mouth, a mass on the
gums, bleeding, odor, or difficulty eating are the signs to watch for. Cancer may also
develop inside the nose—bleeding from the nose, difficulty breathing, or facial swelling
possibly occurring. Lymphoma is characterized by one or many lymph nodes in the body
becoming enlarged.Osteosarcoma: This is the most common bone tumor in dogs. Approximately 8-10,000
dogs are diagnosed with OSA each year. Affected dogs are most commonly large or
giant breed dogs and slightly more are male. The most
common sites are near the wrist and shoulder, as well as near the joints in the
hind leg. This cancer metastasizes frequently as 90% of patients have
micrometastasis (spread of small tumors that we cannot yet see on
x-rays/radiographs) at the time of diagnosis. The treatment of choice is
amputation, although there are both medical and surgical options for limb
sparing depending on what bone is affected. This tumor can also occur in the
head and torso, in non-bone tissues, and in cats. In addition to surgery,
because of the likelihood of early spread of disease (metastasis), chemotherapy
is very important for complete care. With treatment of the affected leg plus
chemotherapy, one year survival rates are around 60%. At the University of
Missouri-Columbia Veterinary Medical Teaching Hospital, they offer novel limb
salvage with Samarium which is a bone-seeking radionuclide, intended primarily
to relieve the pain associated with bone cancer.
Lymphoma: Lymphoma is a common cancer of dogs and cats that can occur anywhere
in the body. Lymphoma is the same as lymphosarcoma, as there is no benign
variant of the disease. In dogs, it is most commonly seen in the lymph nodes. Chemotherapy is typically well tolerated and when
patients are in remission, most pets enjoy a normal or near normal quality of
life. Common sites for lymph nodes are under the jaw, in front of the shoulder,
in the armpit, in the groin, and behind the knee.
Soft tissue sarcomas: These are tumors that originate from the cells that hold
our ‘parts’ together. They have a variety of different names but behave in a
similar manner. Some common tumors in this group include fibrosarcoma,
peripheral nerve sheath tumor, and hemangiopericytoma. These tumors are
typically aggressive locally but less likely to spread throughout the body. They
are treated initially with surgery and when additional therapy is needed, are
well controlled with radiation therapy.
Mast cell tumors: These are common skin tumors found in both dogs and cats.
Their behavior depends on how they look under the microscope. Some tumors stay
where they grow but others can spread to other parts of the body. A biopsy is
required to determine the best treatment for a cat or dog but surgery is usually
the first step. If additional local control is needed, radiation and/or
chemotherapy may be recommended, and if a tumor is high grade and likely to
spread systemically, then chemotherapy will be recommended with or without
radiation. Newer chemotherapy protocols have given more favorable outcomes than
what was reported in the past and local control is excellent with surgery and,
if needed, radiation therapy.
Nasal tumors: Dogs and cats can both get tumors up inside the nasal cavity.
Clinical signs include persistent discharge from the nose on one side, often
with blood. Sometimes nosebleeds are seen. The treatment of choice for nasal
tumors is radiation therapy alone. Surgery does not seem to improve survival and
may cause more discharge, but may be used in select cases. Chemotherapy has been
tried in a few cases but is not as effective as radiation. These tumors can
metastasize but more often the tumor in the nose is the main problem for the
pet. Average survival with radiation therapy is 1-1 ½ yrs, with no treatment,
depending on the clinical signs a dog is experiencing, survival is usually less
than 6 months.
Hemangiosarcoma: This is an aggressive cancer that occurs most often in the
spleen of dogs. It has also been seen in the heart and skin of dogs. It is a
tumor of the blood vessels and since there are blood vessels in every tissue,
this tumor can be seen anywhere in the body. This cancer is highly metastatic
and the treatment of choice is removal of the spleen followed by chemotherapy.
Based on currently available published information, the average survival
following surgery alone is around 2 ½ months and with the addition of
chemotherapy is around 6 months. The exception is with skin lesions which have a
much lower metastatic rate and much longer survival rate.
The following links provide more comprehensive
information on types of canine tumors and cancers.
Anal Sac Gland Tumors
Apocrine Gland Tumors
Basal Cell Tumor
Basosquamous Carcinoma
Benign Melanocytic Tumors
Bone Tumors
Ceruminous Gland Tumors
Chondrosarcoma (Larynx and Trachea)
Chondrosarcoma (Nasal and Paranasal Sinus)
Ear Tumors
Fibrosarcoma (Bone)
Fibrosarcoma (Nasal and
Paranasal Sinus)
Gastrinoma
Gastrointestinal
Neoplasia
Hepatic Neoplasia (Liver Tumors)
Hepatoid Gland Tumors
Hemangiopericytoma (includes
spindle cell sarcomas)
Hemangiosarcoma
Histiocytosis
Leukemia
Liposarcoma
Lymphoma/Lymphosarcoma
Lymphoma/Lymphosarcoma: Relationship
to
Hypercalcemia
Malignant Fibrous Histiocytoma
Mammary Gland Tumors
Mast Cell Tumors
Meibomian Tumors
Meningioma
Nasal Passages Tumors
Osteosarcoma
Papilloma (Papillomatosis)
Prostatic Tumors
Primary Lung Tumors (Pulmonary
Neoplasia)
Renal (Kidney) Neoplasia
Rhabdomyosarcoma
Sebaceous Gland Tumors
Skin Cancer
Squamous Cell Carcinoma
Splenic Masses
Subungual Squamous Cell Carcinoma
Testicular Tumors
Transitional Cell Carcinoma
Transmissible Venereal Tumor
Tumors with Differentiation to Hair
Follicular Structures
Undifferentiated Sarcoma
Urethral Prolapse and Neoplasia
Urinary Bladder Cancer
Uterine Tumors in Dogs
World Health Organization Histological
Classification of Tumors
FAIR USE NOTICE This article contains copyrighted material, the use of
which has not always been specifically authorized by the
copyright owner. I am making such material available in
my efforts to provide background knowledge on areas
related to canine cancer. I believe this constitutes a
'fair use' of any such copyrighted material as provided
for in section 107 of the US Copyright Law. In
accordance with
Title 17 U.S.C. Section 107,
the material in this article is distributed without
profit for educational purposes.
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